Identification of a retrovirus-like repetitive element in human DNA.
نویسندگان
چکیده
منابع مشابه
Human endogenous retrovirus-like sequences.
One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed "provirus", can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to...
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A significant proportion of the human genome consists of interspersed repetitive DNA sequences. One type of repetitive DNA elements is human endogenous retroviruses (HERVs), representing about 1% of the human genome. Their structures closely resemble those of retroviruses, and include internal sequences with homology to gag, pol, and env open reading frames (ORFs) flanked by long terminal repea...
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The presence of a Salmonella serotype Enteritidis repeat element (SERE) located within the upstream regulatory region of the sefABCD operon encoding fimbrial proteins is reported. DNA dot-blot hybridisation analyses and computerised searches of genetic databases indicate that SERE is well conserved and widely distributed throughout the bacterial and archaeal kingdoms. A SERE-based polymerase ch...
متن کاملPrenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta.
BACKGROUND Prenatal exposure to endocrine disrupting compounds (EDCs) has previously shown to alter epigenetic marks. OBJECTIVES In this work we explore whether prenatal exposure to mixtures of xenoestrogens has the potential to alter the placenta epigenome, by studying DNA methylation in retrotransposons as a surrogate of global DNA methylation. METHODS The biomarker total effective xenoes...
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Repetitive elements represent a large portion of the human genome and contain much of the CpG methylation found in normal human postnatal somatic tissues. Loss of DNA methylation in these sequences might account for most of the global hypomethylation that characterizes a large percentage of human cancers that have been studied. There is widespread interest in correlating the genomic 5-methylcyt...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1984
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.81.23.7510